All Publications

  • All Publications

Publications (all)

  1. J. Sapudom, K.T. Nguyen, S. Martin, T. Wippold, S. Moller, M. Schnabelrauch, U. Anderegg, T. Pompe. Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion. Biomater Sci 8:1405 (2020). Open Access Link
  2. J. Doring, D. Rettke, G. Rodel, T. Pompe, K. Ostermann. Surface Functionalization by Hydrophobin-EPSPS Fusion Protein Allows for the Fast and Simple Detection of Glyphosate. Biosensors 9:104 (2019). Open Access Link
  3. F. Ullm, P. Riedl, A. Machado de Amorim, A. Patzschke, R. Weiß, S. Hauschildt, K. Franke, U. Anderegg, T. Pompe. 3D Scaffold-Based Macrophage Fibroblast Coculture Model Reveals IL-10 Dependence of Wound Resolution Phase. Advanced Biosystems 4:1900220 (2019). Open Access Link
  4. A. Muller, S. Muller, V. Nasufovic, H. D. Arndt, and T. Pompe. Actin stress fiber dynamics in laterally confined cells. Integr Biol (Camb) 11:175-85 (2019). Link
  5. J. Waschke, T. Pompe, D. Rettke, S. Schmidt, and M. Hlawitschka. Radial profile detection of multiple spherical particles in contact with interacting surfaces. PLoS One 14:e0214815 (2019). Open Access Link
  6. J. Sapudom, L. Kalbitzer, X. Wu, S. Martin, K. Kroy, and T. Pompe. Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells. Biomaterials 193:47-57 (2019). Link
  7. M. Krater, J. Sapudom, N. C. Bilz, T. Pompe, J. Guck, and C. Claus. Alterations in Cell Mechanics by Actin Cytoskeletal Changes Correlate with Strain-Specific Rubella Virus Phenotypes for Cell Migration and Induction of Apoptosis. Cells 7:136 (2018). Open Access Link
  8. C. Müller, M. Ansorge, M. Espig, S. Zschoche, J. Schiller, and T. Pompe. Covalent Binding of Maleic Anhydride Copolymer Monolayers to Polyacrylamide Hydrogels. Macromol Chem Phys 219:1800206 (2018). Link
  9. J. Sapudom, T. Pompe. Biomimetic tumor microenvironments based on collagen matrices. Biomater Sci 6:2009-24 (2018). Link
  10. M. Ansorge, T. Pompe. Systems for localized release to mimic paracrine cell communication in vitro. J Control Release 278:24-36 (2018). Link
  11. L. Kalbitzer, and T. Pompe. Fibril growth kinetics link buffer conditions and topology of 3D collagen I networks. Acta Biomater 67:206-14 (2018). Link , Open Access Link
  12. E. Muller, T. Pompe, U. Freudenberg, and C. Werner. Solvent-Assisted Micromolding of Biohybrid Hydrogels to Maintain Human Hematopoietic Stem and Progenitor Cells Ex Vivo. Adv Mater 29:1703489 (2017) Link
  13. J. Sapudom, J. Waschke, K. Franke, M. Hlawitschka, and T. Pompe. Quantitative label-free single cell tracking in 3D biomimetic matrices. Sci Rep 7:14135 (2017). Open Access Link
  14. M. Ansorge, J. Sapudom, M. Chkolnikov, M. Wilde, U. Anderegg, S. Moller, M. Schnabelrauch, and T. Pompe. Mimicking Paracrine TGF-beta1 Signals during Myofibroblast Differentiation in 3D Collagen Networks. Sci Rep 7:5664 (2017). Open Access Link
  15. J. Sapudom, X. Wu, M. Chkolnikov, M. Ansorge, U. Anderegg, and T. Pompe. Fibroblast fate regulation by time dependent TGF-beta1 and IL-10 stimulation in biomimetic 3D matrices. Biomater Sci 5:1858-67 (2017). Link
  16. M. Friedemann, L. Kalbitzer, S. Franz, S. Moeller, M. Schnabelrauch, J. C. Simon, T. Pompe and K. Franke. Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks. Adv Healthc Mater  (2017). Link
  17. J. Sapudom, F. Ullm, S. Martin, L. Kalbitzer, J. Naab, S. Moller, M. Schnabelrauch, U. Anderegg, S. Schmidt, and T. Pompe. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater 50:259-70 (2017). Link , Open Access Link
  18. E. Muller, W. Wang, W. Qiao, M. Bornhauser, P. W. Zandstra, C. Werner, and T. Pompe. Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform. Sci Rep 6:31951 (2016). Open Access Link
  19. S. Martin, H. Wang, T. Rathke, U. Anderegg, S. Möller, M. Schnabelrauch, T. Pompe, and S. Schmidt. Polymer hydrogel particles as biocompatible AFM probes to study CD44/hyaluronic acid interactions on cells. Polymer 102:342-9 (2016). Link
  20. J. Sapudom, S. Rubner, S. Martin, and T. Pompe. Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces. Adv Healthc Mater 5:1861-7 (2016). Link
  21. M. Ansorge, N. Rastig, R. Steinborn, T. Konig, L. Baumann, S. Moller, M. Schnabelrauch, M. Cross, C. Werner, A. G. Beck-Sickinger, and T. Pompe. Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J Control Release 224:59-68 (2016). Link , Open Access Link
  22. C. Müller, and T. Pompe. Distinct impacts of substrate elasticity and ligand affinity on traction force evolution. Soft Matter 12:272-80 (2016). Open Access Link
  23. L. Kalbitzer, F. Franke, S. Möller, M. Schnabelrauch, and T. Pompe. Glycosaminoglycan functionalization of mechanically and topologically defined collagen I matrices. J Materials Chemistry B 3:8902-10 (2015). Open Access Link
  24. J. Sapudom, S. Rubner, S. Martin, S. Thoenes, U. Anderegg, and T. Pompe. The interplay of fibronectin functionalization and TGF-beta1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomater Sci 3:1291-301 (2015). Open Access Link
  25. E. Müller, T. Grinenko, T. Pompe, C. Waskow, and C. Werner. Space constraints govern fate of hematopoietic stem and progenitor cells in vitro. Biomaterials 53:709-15 (2015). Link , Open Access Link
  26. J. Sapudom, S. Rubner, S. Martin, T. Kurth, S. Riedel, C. T. Mierke, and T. Pompe. The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. Biomaterials 52:367-75 (2015). Link , Open Access Link
  27. S. Martin, H. Wang, L. Hartmann, T. Pompe, and S. Schmidt. Quantification of protein-materials interaction by soft colloidal probe spectroscopy. Physical chemistry chemical physics : PCCP 17:3014-18 (2015). Open Access Link
  28. E. Bach, T. Zerjatke, M. Herklotz, N. Scherf, D. Niederwieser, I. Roeder, T. Pompe, M. Cross, and I. Glauche. Elucidating functional heterogeneity in hematopoietic progenitor cells: A combined experimental and modeling approach. Exp Hematol 42:826-37 (2014). Link
  29. D. Pussak, D. Ponader, S. Mosca, T. Pompe, L. Hartmann, and S. Schmidt. Specific Adhesion of Carbohydrate Hydrogel Particles in Competition with Multivalent Inhibitors Evaluated by AFM. Langmuir 30:6142-50 (2014). Link
  30. K. Franke, J. Sapudom, L. Kalbitzer, U. Anderegg, and T. Pompe. Topologically defined composites of collagen types I and V as in vitro cell culture scaffolds. Acta Biomater 10:2693-702 (2014). Link , Open Access Link
  31. A. Muller, J. Meyer, T. Paumer, and T. Pompe. Cytoskeletal transition in patterned cells correlates with interfacial energy model. Soft Matter 10:2444-52 (2014). Open Access Link
  32. C. Müller, A. Müller, and T. Pompe. Dissipative Interactions in Cell-Matrix Adhesion. Soft Matter 9:6207-16 (2013). Link
  33. T. Pompe, M. Prewitz, and C. Werner. Polymere Biomaterialien als zelluläre Mikromilieus. Biospektrum 20:383-84 (2012). 
  34. M. Prewitz, F. P. Seib, T. Pompe, and C. Werner. Polymeric Biomaterials for Stem Cell Bioengineering. Macromol Rapid Commun 33:1420-31 (2012). Link
  35. D. Stamov, and T. Pompe. Structure and function of ECM-based composite collagen I scaffolds. Soft Matter 8:10200-12 (2012). Link
  36. H. Perez-Hernandez, T. Paumer, T. Pompe, C. Werner, and A. F. Lasagni. Contactless laser-assisted patterning of surfaces for bio-adhesive microarrays. Biointerphases 7:35-43 (2012). Open Access Link
  37. N. Zhang, T. Pompe, I. Amin, R. Luxenhofer, C. Werner, and R. Jordan. Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromol Biosci 12:926-36 (2012). Link
  38. C. Müller, D. Stamov, C. Werner, and T. Pompe. Nanoscale Characterization of Cell Receptors and Binding Sites on Cell-Derived Extracellular Matrices. Ultramicroscopy 118:44-52 (2012). Link
  39. J. Teichmann, A. Morgenstern, J. Seebach, H. J. Schnittler, C. Werner, and T. Pompe. The control of endothelial cell adhesion and migration by shear stress and matrix-substrate anchorage. Biomaterials 33:1959-69 (2012). Link
  40. N. Scherf, K. Franke, I. Glauche, I. Kurth, M. Bornhäuser, C. Werner, T. Pompe, and I. Roeder. On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup. Exp Hematol 40:119-30 (2012). Link
  41. I. Roeder, M. Loeffler, and I. Glauche. Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies. Blood Cells Mol Dis 46:308-17 (2011). Link
  42. D. R. Stamov, T. A. Khoa Nguyen, H. M. Evans, T. Pfohl, C. Werner, and T. Pompe. The impact of heparin intercalation at specific binding sites in telopeptide-free collagen type I fibrils. Biomaterials 32:7444-53 (2011). Link
  43. I. Kurth, K. Franke, T. Pompe, M. Bornhauser, and C. Werner. Extracellular matrix functionalized microcavities to control hematopoietic stem and progenitor cell fate. Macromol Biosci 11:739-47 (2011). Link
  44. M. Kaufmann, Y. Jia, C. Werner, and T. Pompe. Weakly coupled lipid bilayer membranes on multistimuli-responsive poly(N-isopropylacrylamide) copolymer cushions. Langmuir 27:513-6 (2011). Link
  45. T. Pompe, M. Kaufmann, M. Kasimir, S. Johne, S. Glorius, L. Renner, M. Bobeth, W. Pompe, and C. Werner. Friction controled traction forces in cell adhesion. Biophys J 101:1863-70 (2011). Open Access Link
  46. L. Renner, T. Pompe, R. Lemaitre, D. Drechsel, and C. Werner. Controlled enhancement of transmembrane enzyme activity in polymer cushioned supported bilayer membranes. Soft Matter 6:5382-89 (2010). Link
  47. T. Pompe, K. Salchert, K. Alberti, P. Zandstra, and C. Werner. Immobilization of growth factors on solid supports for the modulation of stem cell fate. Nat Protoc 5:1042-50 (2010). Link
  48. K. Lehmann, M. Herklotz, M. Espig, T. Paumer, M. Nitschke, C. Werner, and T. Pompe. A new approach to biofunctionalisation and micropatterning of multi-well plates. Biomaterials 31:8802-9 (2010). Link
  49. M. Kaufmann, Y. F. Jia, L. Renner, S. Gupta, D. Kuckling, C. Werner, and T. Pompe. Tuneable swelling of thermo- and pH-responsive copolymer films. Soft Matter 6:937-44 (2010). Link
  50. R. Grombe, M. F. Gouzy, U. Freudenberg, T. Pompe, S. Zschoche, F. Simon, K. J. Eichhorn, A. Janke, B. Voit, and C. Werner. Sulfated cellulose thin films with antithrombin affinity. Express Polym Lett 3:733-42 (2009). Open Access Link
  51. T. Pompe, S. Glorius, T. Bischoff, I. Uhlmann, M. Kaufmann, S. Brenner, and C. Werner. Dissecting the impact of matrix anchorage and elasticity in cell adhesion. Biophys J 97:2154-63 (2009). Open Access Link
  52. K. Franke, I. Kurth, M. Bornhäuser, C. Werner, and T. Pompe. Biomimetic Microcavities Based on Poly(dimethylsiloxane) Elastomers. Soft Matter 5:3505-10 (2009). Link
  53. D. Stamov, K. Salchert, A. Springer, C. Werner, and T. Pompe. Structural Polymorphism of Collagen Type I - Heparin Cofibrils. Soft Matter 5:3461-8 (2009). Link
  54. I. Kurth, K. Franke, T. Pompe, M. Bornhäuser, and C. Werner. Hematopoietic stem and progenitor cells in adhesive microcavities. Integr Biol 1:427-34 (2009). Link
  55. L. Renner, T. Pompe, and C. Werner. Electrostatic stretching of grafted maleic acid copolymer chains. Express Polym Lett 3:33-38 (2009). Open Access Link
  56. Z. Oezyuerek, K. Franke, M. Nitschke, R. Schulze, F. Simon, K. J. Eichhorn, T. Pompe, C. Werner, and B. Voit. Sulfated glyco-block copolymers with specific receptor and growth factor binding to support cell adhesion and proliferation. Biomaterials 30:1026-35 (2009). Link
  57. M. Herklotz, C. Werner, and T. Pompe. The impact of primary and secondary ligand coupling on extracellular matrix characteristics and formation of endothelial capillaries. Biomaterials 30:35-44 (2008). Link
  58. K. Alberti, R. E. Davey, K. Onishi, S. George, K. Salchert, F. P. Seib, M. Bornhauser, T. Pompe, A. Nagy, C. Werner, and P. W. Zandstra. Functional immobilization of signaling proteins enables control of stem cell fate. Nat Methods 5:645-50 (2008). Link
  59. L. Renner, T. Osaki, S. Chiantia, P. Schwille, T. Pompe, and C. Werner. Supported Lipid Bilayers on Spacious and pH-Responsive Polymer Cushions with Varied Hydrophilicity. J Phys Chem B 112:6373-78 (2008). Link
  60. D. Stamov, M. Grimmer, K. Salchert, T. Pompe, and C. Werner. Heparin intercalation into reconstituted collagen I fibrils: Impact on growth kinetics and morphology. Biomaterials 29:1-14 (2008). Link
  61. M. Herklotz, M. Melamed, C. Trautmann, M. Nitschke, T. Pompe, F. U. Gast, F. Howitz, and C. Werner. Non-contact printing of proteins on reactive polymer surfaces: a novel route towards structured and graded cell culture carriers. Microfluid Nanofluid 3:629-33 (2007). Link
  62. R. Grombe, M. F. Gouzy, M. F. Maitz, U. Freundenberg, S. Zschoche, F. Simon, T. Pompe, C. Sperling, and C. Werner. Sulfated glycopolymer thin films - preparation, characterization, and biological activity. Macromol Biosci 7:195-200 (2007). Link
  63. K. Franke, T. Pompe, M. Bornhauser, and C. Werner. Engineered matrix coatings to modulate the adhesion of CD133(+) human hematopoietic progenitor cells. Biomaterials 28:836-43 (2007). Link
  64. T. Pompe, K. Keller, G. Mothes, M. Nitschke, M. Teese, R. Zimmermann, and C. Werner. Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion. Biomaterials 28:28-37 (2007). Link
  65. M. F. Gouzy, C. Sperling, K. Salchert, T. Pompe, C. Rauwolf, and C. Werner. Benzamidine-based coatings: Implication of inhibitor structure on the inhibition of coagulation enzymes in solution and in vitro hemocompatibility assessment. Biointerphases 1:146-55 (2006). Open Access Link
  66. T. Pompe, J. Starruss, M. Bobeth, and W. Pompe. Modeling of pattern development during fibronectin nanofibril formation. Biointerphases 1:93-97 (2006). Open Access Link
  67. T. Pompe, L. Renner, M. Grimmer, N. Herold, and C. Werner. Functional Films of Maleic Anhydride Copolymers under Physiological Conditions. Macromol Biosci 5:890-95 (2005). Link
  68. T. Pompe, K. Keller, C. Mitdank, and C. Werner. Fibronectin Fibril Pattern Displays the Force Balance of Cell-Matrix Adhesion  Eur Biophys J 34:1049-56 (2005). Link
  69. L. Renner, T. Pompe, K. Salchert, and C. Werner. Fibronectin Displacement at Polymer Surfaces. Langmuir 21:4571-77 (2005). Link
  70. T. Pompe, L. Renner, and C. Werner. Nanoscale Features of Fibronectin Fibrillogenesis Depend on Protein-Substrate Interaction and Cytoskeleton Structure. Biophys J 88:527-34 (2005). Open Access Link
  71. K. Salchert, U. Streller, T. Pompe, N. Herold, M. Grimmer, and C. Werner. In Vitro Reconstitution of Fibrillar Collagen Type I Assemblies at Reactive Polymer Surfaces. Biomacromolecules 5:1340-50 (2004). Link
  72. L. Renner, B. Jorgensen, M. Markowski, K. Salchert, C. Werner, and T. Pompe. Control o fibronectin displacement on polymer substrates to influence endothelial cell behaviour. J Mater Sci Mater Med 15:385-88 (2004). Link
  73. M. F. Gouzy, C. Sperling, K. Salchert, T. Pompe, U. Streller, P. Uhlmann, C. Rauwolf, F. Simon, F. Böhme, B. Voit, and C. Werner. In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative. Biomaterials 25:3493-501 (2004). Link
  74. L. Renner, T. Pompe, K. Salchert, and C. Werner. Dynamic Alterations of Fibronectin Layers on Copolymer Substrates with Graded Physicochemical Characteristics. Langmuir 20:2928-33 (2004). Link
  75. T. Pompe, C. Mitdank, and C. Werner. Quantitative Analysis of Fibronectin Fibrillogenesis by Endothelial Cells on Biomaterials. J Phys: Cond Mat 16:S2421-S26 (2004). Link
  76. T. Pompe, M. Markowski, and C. Werner. Modulated Fibronectin Anchorage at Polymer Substrates Controls Angiogenesis. Tissue Eng 10:841-48 (2004). Link
  77. J. Oswald, B. Jorgensen, T. Pompe, F. Kobe, K. Salchert, M. Bornhauser, G. Ehninger, and C. Werner. Comparison of flow cytometry and laser scanning cytometry for the analysis of CD34+ hematopoietic stem cells. Cytometry 57A:100-07 (2004). Link
  78. K. Salchert, T. Pompe, C. Sperling, and C. Werner. Quantitative analysis of immobilized proteins and protein mixtures by amino acid analysis. J Chromatogr 1005:113-22 (2003). Link
  79. T. Pompe, F. Kobe, K. Salchert, B. Jorgensen, J. Oswald, and C. Werner. Fibronectin anchorage to polymer substrates controls the initial phase of endothelial cell adhesion. J Biomed Mater Res A 67:647-57 (2003). Link
  80. T. Pompe, S. Zschoche, N. Herold, K. Salchert, M. F. Gouzy, C. Sperling, and C. Werner. Maleic anhydride copolymers-a versatile platform for molecular biosurface engineering. Biomacromolecules 4:1072-79 (2003). Link
  81. T. Pompe. Line tension behavior of a first-order wetting system. Phys Rev Lett 89:076102 (2002). Link
  82. S. Herminghaus, T. Pompe, and A. Fery. Scanning Force Investigation of Liquid Structures and its Application to Fundamental Wetting Research. J Adh Sci Technol 14:1767-82 (2000). Link
  83. T. Pompe, and S. Herminghaus. Three-phase contact line energetics from nanoscale liquid surface topographies. Phys Rev Lett 85:1930-33 (2000). Link
  84. S. Herminghaus, A. Fery, S. Schlagowski, K. Jacobs, R. Seemann, H. Gau, W. Mönch, and T. Pompe. Liquid microstructures at solid interfaces. J Phys: Cond Mat 12:A57-A74 (2000). Link
  85. T. Pompe, A. Fery, and S. Herminghaus. Measurement of Contact Line Tension by Analysis of the Three-Phase Boundary with Nanometer Resolution. J Adhesion Sci Technol 13:1155-64 (1999). Link
  86. A. Fery, T. Pompe, and S. Herminghaus. Nanometer Resolution of Liquid Surface Topography by Scanning Force Microscopy. J Adhesion Sci Technol 13:1071-83 (1999). Link
  87. T. Pompe, A. Fery, A. Kriele, H. Lorenz, and J. P. Kotthaus. Submicron Contact Printing on Silicon Using Stamp Pads. Langmuir 15:2398-401 (1999). Link
  88. T. Pompe, S. Herminghaus, and A. Fery. Imaging Liquid Structures on Inhomogeneous Substrates by Scanning Force Microscopy. Langmuir 14:2585-88 (1998). Link
  89. T. Pompe, V. Srikant, and D. R. Clarke. Acoustoelectric current saturation in c-axis fiber-textured polycrystalline zinc oxide films. Appl Phys Lett 69:4065-67 (1996). Link
letzte Änderung: 12.03.2020


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Susanne Vogt
Raum 1.36

Telefon: +49 341 97-36780
Telefax: +49 341 97-36939


New Paper on Soft Colloidal Probe Based Glyphosat Biosensor


Together with collaborators we published a paper in Biosensors & Bioelectronics. Using biomimetic principles and the soft colloidal probe technique we...

New Paper on Role of Hyaluronan in Melanoma Progression


Together with collaborators we published a paper in Biomaterials Science. We show by in vitro results that not the amount of hyaluronan but its low...

New Paper on 3D Matrix-Based Macrophage-Fibroblast Coculture


Together with other groups from Leipzig we published a paper in Advanced Biosystems. Therein we introduce a coculture of primary human macrophages and...