Biophysikalische Chemie


Synthetic and naturally derived polymer matrices are used to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation and transport.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies to reduce animal experiments.

In a second research area we apply bio-/polymer materials to develop biosensors for the detection of anthropogenic analytes in aqueous environments. The technologies are based on specific receptor-ligand interactions of functionalized hydrogel microparticles and nanoparticles.

letzte Änderung: 12.08.2019


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Susanne Vogt
Raum 1.36

Telefon: +49 341 97-36780
Telefax: +49 341 97-36939


New Paper on Soft Colloidal Probe Based Glyphosat Biosensor


Together with collaborators we published a paper in Biosensors & Bioelectronics. Using biomimetic principles and the soft colloidal probe technique we...

New Paper on Role of Hyaluronan in Melanoma Progression


Together with collaborators we published a paper in Biomaterials Science. We show by in vitro results that not the amount of hyaluronan but its low...

New Paper on 3D Matrix-Based Macrophage-Fibroblast Coculture


Together with other groups from Leipzig we published a paper in Advanced Biosystems. Therein we introduce a coculture of primary human macrophages and...