Biophysikalische Chemie

Mission

Synthetic and naturally derived polymer matrices are used to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation and transport.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies to reduce animal experiments.


In a second research area we apply bio-/polymer materials to develop biosensors for the detection of anthropogenic analytes in aqueous environments. The technologies are based on specific receptor-ligand interactions of functionalized hydrogel microparticles and nanoparticles.

letzte Änderung: 12.08.2019

Kontakt

Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939
E-Mail

Sekretariat
Susanne Vogt
Raum 1.36

Telefon: +49 341 97-36780
Telefax: +49 341 97-36939
E-Mail

News

New Paper on the Impact of Fibronectin on Macrophage Polarisation

01.12.2020

Together with collaborators from Radboud University, Nijmegen we published a paper in Biomaterials. Using recently established gene expression markers...

New Paper on Matrix Reorganisation by Myofibroblasts and Cancer-associated Fibroblasts

30.09.2020

Together with collaborators from the Medical Faculty we published a paper in Gels. Within 3D collagen matrices we studied the differences in matrix...

New Paper on Bone Marrow Stromal Cell Differentiation in 3D Collagen Networks

25.09.2020

Together with collaborators we published a paper in ACS Bio Materials. Our established platform of 3D collagen matrices was used to study osteogenic...