Biophysikalische Chemie

Mission

Synthetic and naturally derived polymer matrices are used to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation and transport.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies to reduce animal experiments.


In a second research area we apply bio-/polymer materials to develop biosensors for the detection of anthropogenic analytes in aqueous environments. The technologies are based on specific receptor-ligand interactions of functionalized hydrogel microparticles and nanoparticles.

letzte Änderung: 12.08.2019

Kontakt

Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939
E-Mail

Sekretariat
Susanne Vogt
Raum 1.36

Telefon: +49 341 97-36780
Telefax: +49 341 97-36939
E-Mail

News

New Paper on 3D Matrix-Based Macrophage-Fibroblast Coculture

06.12.2019

Together with other groups from Leipzig we published a paper in Advanced Biosystems. Therein we introduce a coculture of primary human macrophages and...

New Paper on a Glyphosat Detection Assay

29.08.2019

Together with a collaborating group from Technische Universität Dresden we published a new paper in Biosensors. Therein we introduce a new, fast and...

New Paper on Actin Stress Fiber Dynamics

14.08.2019

Our group published a new paper in Integrative Biology. We quantified pattern formation and remodelling of actin stress fibers in laterally confined...